Celiac Disease Panel - Pediatric
Order Name
PED CELIAC
Test Number: 5537675
Revision Date 04/03/2024
Test Number: 5537675
Revision Date 04/03/2024
| Test Name | Methodology | LOINC Code |
|---|---|---|
|
Tissue Transglutaminase IgA (IgA anti-tTG)
|
Chemiluminescence Assay | 46128-5 |
|
Gliadin Deamidated Antibody, IgA
|
Chemiluminescence Assay | 63453-5 |
|
Immunoglobulin IgA Quantitative
|
Turbidometric | 2458-8 |
|
.Celiac Pediatric Interp
|
Interpretive information. |
| SPECIMEN REQUIREMENTS | ||||
|---|---|---|---|---|
| Specimen | Specimen Volume (min) | Specimen Type | Specimen Container | Transport Environment |
| Preferred | 1 mL (0.5 mL) | Serum | Clot Activator SST | Refrigerated |
| Instructions | Allow specimen to clot completely at room temperature. Separate serum from cells ASAP or within 2 hours of collection. Stability After separation from cells: Ambient 8 hours, Refrigerated 2 days, Frozen 30 days (avoid repeated freeze/thaw cycles). |
|||
| GENERAL INFORMATION | |
|---|---|
| Testing Schedule | Mon, Wed, Fri |
| Expected TAT | 2-5 Days |
| Clinical Use | Serologic testing for Celiac Disease (CD) in children less than 3 years of age should be interpreted knowing that the IgA anti-tissue Transglutaminase (IgA anti-tTG) is approximately 90% sensitive in children of this age. In older children and adults, the sensitivity increases to 96%. In children less than 3 years of age, IgG anti-tTG is not reliable. IgA deficiency is 10-15 times more common in patients with CD, occurring in an estimated 2-3% of the patients with CD. IgA and IgG anti-deaminated gliadin peptide (DGP) are also useful markers in CD. |
| Notes | Recent literature has reported that Celiac disease (CD) is a more common disorder in the United States than previously recognized. |
| CPT Code(s) | 86258 82784, 86364 |
| Internal Comments | OLDER CLINICAL USE REMOVED 10-22-15 -JK Evaluation of Celiac Disease in pediatric patients less than 3 years of age. In toddlers, IgG anti-tTG is not reliable, and referral for a small bowel biopsy is recommended for those with serum IgA deficiency. 10/20/17 stab - JK 5/15/18 stab again - JK 1/11/24 - JK - The Tissue Transglutaminase IgA (IgA anti-tTG) is CPT 86364. 2022 cpt from 83516 to 86364 - JK from 83516x2; 82784 to 83516 82784, 86364 5537675( Ped Celiac pnl) - change cpt on Deaminated gliadin ab IgA from 83516 to 86258; - JK 4/3/24 |
| Service Provided By |  |
| Lab Section | Immunology - Serology |