ALK-EML4 gene fusion by FISH
Order Name
ALK FISH
Test Number: 9100787
Revision Date 10/01/2022
Test Number: 9100787
Revision Date 10/01/2022
| Test Name | Methodology | LOINC Code |
|---|---|---|
|
ALK-EML4 gene fusion by FISH
|
Fluorescence in Situ Hybridization |
| SPECIMEN REQUIREMENTS | ||||
|---|---|---|---|---|
| Specimen | Specimen Volume (min) | Specimen Type | Specimen Container | Transport Environment |
| Preferred | See Below | Tissue | Paraffin Block | Room Temperature |
| Instructions | Formalin fixed paraffin embedded tissue. Tissue source and block ID containing tumor are required on the requisition form. Pathology permission is required for any alternate sample types. |
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| GENERAL INFORMATION | |
|---|---|
| Testing Schedule | Tuesday, Thursday |
| Expected TAT | 7 Days |
| Clinical Use | Cinicial use: Rearrangements of the ALK (anaplastic large cell lymphoma) gene located at chromosome 2p23 is best detected by FISH analysis. Patients with lung adenocarcinoma carrying the ALK - EML4 gene fusion have been reported to have a good response to certain chemotherapeutic medications. |
| CPT Code(s) | 88377 |
| Internal Comments | original clinical use: The anaplastic large cell lymphoma specific chromosomal rearrangements of 2p23 can be proved by FISH. The patients carrying t (2; 5) or ALK fusion protein have been reported to have a good response to chemotherapy and favorable outcome. 5/11/18 changed from 88368x2 to 88377 - JK 6/19/2020 updated the sched and tat - JK |
| Service Provided By |  |
| Lab Section | Reference Lab |