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St. John Health System
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14-3-3 Protein Tau/Theta with RT-QuIC Analysis

Order Name 14-3-3 PROT
Test Number: 6006447
Revision Date 08/30/2024
Test Name Methodology LOINC Code
14-3-3 Protein Tau/Theta with RT-QuIC Analysis
Western Blot/Quantitative ELISA/RT-QuIC Analysis  
SPECIMEN REQUIREMENTS
Specimen Specimen Volume (min) Specimen Type Specimen Container Transport Environment
Preferred 5 mL (2 mL) CSF (Cerebrospinal Fluid) Sarstedt Polypropylene (PP) low binding, sterile collection tube Frozen
Instructions Specimen Type:Sarstedt Polypropylene (PP) low binding, sterile collection tube PS# 140857 (5 tubes) or 140688 for case of 100"
Patient Preparation: Patient must be 12 years of age or older" has been added; Causes for Rejection “Bloody and insufficient sample quantity. Samples that are colored or contain blood cannot be performed for RT-QualC and 14-3-3 GAMMA
Special Instructions: Testing referred to National Prion Disease Path. Surv. Center MDCOW#-
Storage Instructions: FREEZE as quickly as possible (preferably within 20 minutes of collection). If possible store at -80'C. Put on dry ice as soon as possible.
Specimen Stability: Ambient: Not Available, Refrigerated : Not Available, Frozen: Indefinitely
GENERAL INFORMATION
Expected TAT N/A 
Clinical Use This test includes RT-QuIC Analysis (by Real-Time Quaking-Induced Conversion) with every order.  
Notes Labcorp Test Code: 081695
CPT Code(s) 83520x2
Internal Comments 7/27/17 Removed the reflex to the 6006449 Reflex to RT-QuIC Analysis, CSF per ARUP hotline for July 3 2017
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If positive this test will reflex to Reflex Code: 6006449 Reflex to RT-QuIC Analysis, CSF
by Real-Time Quaking-Induced Conversion.
CPT: 87798
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11-12-17 added link to ARUP - JK
12/29/18 - Updated CPT (SN)
11/18/19: Updated instructions (SN)
Service Provided By Labcorp Oklahoma, Inc.
Lab Section Reference Lab